منابع مشابه
The human gut virome: a multifaceted majority
Here, we outline our current understanding of the human gut virome, in particular the phage component of this ecosystem, highlighting progress, and challenges in viral discovery in this arena. We reveal how developments in high-throughput sequencing technologies and associated data analysis methodologies are helping to illuminate this abundant 'biological dark matter.' Current evidence suggests...
متن کاملRapid evolution of the human gut virome.
Humans are colonized by immense populations of viruses, which metagenomic analysis shows are mostly unique to each individual. To investigate the origin and evolution of the human gut virome, we analyzed the viral community of one adult individual over 2.5 y by extremely deep metagenomic sequencing (56 billion bases of purified viral sequence from 24 longitudinal fecal samples). After assembly,...
متن کاملHuman Virome
Viruses are dominant entities in the biosphere and parasitize all cellular life forms. The relative abundances of different classes of viruses are dramatically different between prokaryotes and eukaryotes. In marine, soil and animal-associated environments, virus particles consistently outnumber cells by one to two orders of magnitude. It is estimated that 10 quintillion (1030) viral particles ...
متن کاملGut Inflammation and Immunity: What Is the Role of the Human Gut Virome?
The human virome comprises viruses that infect host cells, virus-derived elements in our chromosomes, and viruses that infect other organisms, including bacteriophages and plant viruses. The development of high-throughput sequencing techniques has shown that the human gut microbiome is a complex community in which the virome plays a crucial role into regulation of intestinal immunity and homeos...
متن کاملExpanding the role of the virome: commensalism in the gut.
Viruses affect host physiology beyond causing acute disease, thereby giving rise to the concept that the virome is a component of the microbiome. However, the role of the enteric virome is understudied relative to the fast-paced research examining commensal bacteria in the intestine. In this article, I discuss our recent work on murine norovirus indicating that an animal virus in the intestine ...
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ژورنال
عنوان ژورنال: Emerging Topics in Life Sciences
سال: 2017
ISSN: 2397-8554,2397-8562
DOI: 10.1042/etls20170039